home *** CD-ROM | disk | FTP | other *** search
| Unknown | 1992-06-06 | 301.8 KB |
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MacOS 8.1
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Win98
|
DOS
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| Confidence | Program | Detection | Match Type | Support
|
|---|
| 66%
| dexvert
| OS/2 Installation Package (archive/os2InstallPackage)
| ext
| Supported |
| 1%
| dexvert
| BeOS Installation Package (archive/beOSInstallPackage)
| ext
| Unsupported |
| 1%
| dexvert
| Newton Package (archive/newtonPackage)
| ext
| Unsupported |
| 1%
| dexvert
| Independence War 2 mod Package (other/independenceWar2ModPackage)
| ext
| Unsupported |
| 100%
| file
| data
| default
|
|
hex view+--------+-------------------------+-------------------------+--------+--------+
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|00000010| 00 00 16 00 00 00 30 30 | 00 00 00 01 8e 05 00 00 |......00|........|
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|00000450| 00 01 24 ac 03 00 be 11 | 00 00 37 39 00 00 00 01 |..$.....|..79....|
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|00000470| 03 00 c6 0a 00 00 38 31 | 00 00 00 01 8b d7 03 00 |......81|........|
|00000480| 7d 0f 00 00 38 32 00 00 | 00 01 08 e7 03 00 5f 0b |}...82..|......_.|
|00000490| 00 00 38 33 00 00 00 01 | 67 f2 03 00 e5 09 00 00 |..83....|g.......|
|000004a0| 38 34 00 00 00 01 4c fc | 03 00 b3 0b 00 00 38 35 |84....L.|......85|
|000004b0| 00 00 00 01 ff 07 04 00 | 0d 0a 00 00 38 36 00 00 |........|....86..|
|000004c0| 00 01 0c 12 04 00 8b 0b | 00 00 38 37 00 00 00 01 |........|..87....|
|000004d0| 97 1d 04 00 a9 0b 00 00 | 38 38 00 00 00 01 40 29 |........|88....@)|
|000004e0| 04 00 08 0b 00 00 38 39 | 00 00 00 01 48 34 04 00 |......89|....H4..|
|000004f0| 8d 0b 00 00 39 30 00 00 | 00 01 d5 3f 04 00 9e 0d |....90..|...?....|
|00000500| 00 00 39 31 00 00 00 01 | 73 4d 04 00 f4 09 00 00 |..91....|sM......|
|00000510| 39 32 00 00 00 01 67 57 | 04 00 53 0a 00 00 39 33 |92....gW|..S...93|
|00000520| 00 00 00 01 ba 61 04 00 | d4 08 00 00 39 34 00 00 |.....a..|....94..|
|00000530| 00 01 8e 6a 04 00 17 0b | 00 00 39 35 00 00 00 01 |...j....|..95....|
|00000540| a5 75 04 00 c2 0f 00 00 | 39 36 00 00 00 01 67 85 |.u......|96....g.|
|00000550| 04 00 4d 0b 00 00 39 37 | 00 00 00 01 b4 90 04 00 |..M...97|........|
|00000560| 37 0a 00 00 39 38 00 00 | 00 01 eb 9a 04 00 e0 0e |7...98..|........|
|00000570| 00 00 39 39 00 00 00 01 | cb a9 04 00 63 0d 00 00 |..99....|....c...|
|00000580| 00 00 00 00 00 00 2e b7 | 04 00 00 00 00 00 24 55 |........|......$U|
|00000590| 6e 69 71 75 65 5f 49 44 | 7b 59 52 42 30 34 38 30 |nique_ID|{YRB0480|
|000005a0| 30 7d 0d 0a 24 54 69 74 | 6c 65 7b 54 68 65 20 50 |0}..$Tit|le{The P|
|000005b0| 72 65 76 61 6c 65 6e 63 | 65 20 6f 66 20 54 68 79 |revalenc|e of Thy|
|000005c0| 72 6f 69 64 20 41 75 74 | 6f 61 6e 74 69 62 6f 64 |roid Aut|oantibod|
|000005d0| 69 65 73 20 69 6e 20 44 | 65 72 6d 61 74 69 74 69 |ies in D|ermatiti|
|000005e0| 73 20 48 65 72 70 65 74 | 69 66 6f 72 6d 69 73 7d |s Herpet|iformis}|
|000005f0| 0d 0a 24 41 75 74 68 6f | 72 7b 0d 0a 57 65 65 74 |..$Autho|r{..Weet|
|00000600| 6d 61 6e 2c 20 41 50 0d | 0a 42 75 72 72 69 6e 2c |man, AP.|.Burrin,|
|00000610| 20 4a 4d 0d 0a 4d 61 63 | 6b 61 79 2c 20 44 0d 0a | JM..Mac|kay, D..|
|00000620| 4c 65 6f 6e 61 72 64 2c | 20 4a 4e 0d 0a 47 72 69 |Leonard,| JN..Gri|
|00000630| 66 66 69 74 68 73 2c 20 | 43 45 4d 0d 0a 46 72 79 |ffiths, |CEM..Fry|
|00000640| 2c 20 4c 7d 0d 0a 24 41 | 66 66 69 6c 69 61 74 69 |, L}..$A|ffiliati|
|00000650| 6f 6e 7b 52 6f 79 61 6c | 20 50 6f 73 74 67 72 61 |on{Royal| Postgra|
|00000660| 64 75 61 74 65 20 4d 65 | 64 20 53 63 68 6f 6f 6c |duate Me|d School|
|00000670| 2c 20 4c 6f 6e 64 6f 6e | 3b 20 53 74 20 4d 61 72 |, London|; St Mar|
|00000680| 79 27 73 20 48 6f 73 70 | 2c 20 4c 6f 6e 64 6f 6e |y's Hosp|, London|
|00000690| 7d 0d 0a 24 53 75 62 6a | 65 63 74 7b 54 68 79 72 |}..$Subj|ect{Thyr|
|000006a0| 6f 69 64 20 61 75 74 6f | 61 6e 74 69 62 6f 64 69 |oid auto|antibodi|
|000006b0| 65 73 20 69 6e 20 64 65 | 72 6d 61 74 69 74 69 73 |es in de|rmatitis|
|000006c0| 20 68 65 72 70 65 74 69 | 66 6f 72 6d 69 73 3b 0d | herpeti|formis;.|
|000006d0| 0a 44 65 72 6d 61 74 69 | 74 69 73 20 68 65 72 70 |.Dermati|tis herp|
|000006e0| 65 74 69 66 6f 72 6d 69 | 73 20 74 68 79 72 6f 69 |etiformi|s thyroi|
|000006f0| 64 20 61 75 74 6f 61 6e | 74 69 62 6f 64 69 65 73 |d autoan|tibodies|
|00000700| 20 69 6e 3b 0d 0a 41 75 | 74 6f 61 6e 74 69 62 6f | in;..Au|toantibo|
|00000710| 64 69 65 73 20 74 68 79 | 72 6f 69 64 2c 20 69 6e |dies thy|roid, in|
|00000720| 20 64 65 72 6d 61 74 69 | 74 69 73 20 68 65 72 70 | dermati|tis herp|
|00000730| 65 74 69 66 6f 72 6d 69 | 73 3b 0d 0a 41 6e 74 69 |etiformi|s;..Anti|
|00000740| 62 6f 64 79 28 69 65 73 | 29 20 74 68 79 72 6f 69 |body(ies|) thyroi|
|00000750| 64 20 61 75 74 6f 61 6e | 74 69 62 6f 64 69 65 73 |d autoan|tibodies|
|00000760| 20 69 6e 20 64 65 72 6d | 61 74 69 74 69 73 20 68 | in derm|atitis h|
|00000770| 65 72 70 65 74 69 66 6f | 72 6d 69 73 7d 0d 0a 24 |erpetifo|rmis}..$|
|00000780| 4a 6f 75 72 6e 61 6c 7b | 42 72 20 4a 20 44 65 72 |Journal{|Br J Der|
|00000790| 6d 61 74 6f 6c 7d 0d 0a | 24 56 6f 6c 75 6d 65 7b |matol}..|$Volume{|
|000007a0| 31 31 38 7d 0d 0a 24 50 | 61 67 65 7b 33 37 37 2d |118}..$P|age{377-|
|000007b0| 33 38 33 7d 0d 0a 24 44 | 61 74 65 7b 4d 61 72 63 |383}..$D|ate{Marc|
|000007c0| 68 20 31 39 38 38 7d 0d | 0a 24 59 42 56 6f 6c 7b |h 1988}.|.$YBVol{|
|000007d0| 31 39 38 39 20 59 65 61 | 72 20 42 6f 6f 6b 20 6f |1989 Yea|r Book o|
|000007e0| 66 20 44 65 72 6d 61 74 | 6f 6c 6f 67 79 7d 0d 0a |f Dermat|ology}..|
|000007f0| 24 43 68 61 70 74 65 72 | 7b 33 2d 31 36 7d 0d 0a |$Chapter|{3-16}..|
|00000800| 24 59 42 45 64 69 74 6f | 72 7b 44 72 73 2e 20 53 |$YBEdito|r{Drs. S|
|00000810| 6f 62 65 72 20 61 6e 64 | 20 46 69 74 7a 70 61 74 |ober and| Fitzpat|
|00000820| 72 69 63 6b 7d 0d 0a 24 | 54 61 62 6c 65 7b 7d 0d |rick}..$|Table{}.|
|00000830| 0a 24 43 6f 6d 6d 65 6e | 74 61 74 6f 72 7b 52 2e |.$Commen|tator{R.|
|00000840| 20 4d 61 73 74 65 72 73 | 2c 20 4d 2e 44 2e 7d 0d | Masters|, M.D.}.|
|00000850| 0a 0d 0a 43 6f 70 79 72 | 69 67 68 74 20 28 63 29 |...Copyr|ight (c)|
|00000860| 20 59 65 61 72 20 42 6f | 6f 6b 20 4d 65 64 69 63 | Year Bo|ok Medic|
|00000870| 61 6c 20 50 75 62 6c 69 | 73 68 65 72 73 2c 20 49 |al Publi|shers, I|
|00000880| 6e 63 2e 2c 20 31 39 38 | 39 0d 0a 0d 0a 31 39 38 |nc., 198|9....198|
|00000890| 39 20 59 65 61 72 20 42 | 6f 6f 6b 20 6f 66 20 44 |9 Year B|ook of D|
|000008a0| 65 72 6d 61 74 6f 6c 6f | 67 79 20 28 52 29 0d 0a |ermatolo|gy (R)..|
|000008b0| 0d 0a 43 68 61 70 74 65 | 72 20 33 2d 2d 42 75 6c |..Chapte|r 3--Bul|
|000008c0| 6c 6f 75 73 20 44 69 73 | 65 61 73 65 73 0d 0a 0d |lous Dis|eases...|
|000008d0| 0a 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |.-------|--------|
|000008e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000008f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000900| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000910| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000920| 2d 0d 0a 54 68 65 20 50 | 72 65 76 61 6c 65 6e 63 |-..The P|revalenc|
|00000930| 65 20 6f 66 20 54 68 79 | 72 6f 69 64 20 41 75 74 |e of Thy|roid Aut|
|00000940| 6f 61 6e 74 69 62 6f 64 | 69 65 73 20 69 6e 20 44 |oantibod|ies in D|
|00000950| 65 72 6d 61 74 69 74 69 | 73 20 48 65 72 70 65 74 |ermatiti|s Herpet|
|00000960| 69 66 6f 72 6d 69 73 0d | 0a 0d 0a 57 65 65 74 6d |iformis.|...Weetm|
|00000970| 61 6e 20 41 50 3b 20 42 | 75 72 72 69 6e 20 4a 4d |an AP; B|urrin JM|
|00000980| 3b 20 4d 61 63 6b 61 79 | 20 44 3b 20 4c 65 6f 6e |; Mackay| D; Leon|
|00000990| 61 72 64 20 4a 4e 3b 20 | 47 72 69 66 66 69 74 68 |ard JN; |Griffith|
|000009a0| 73 20 43 45 4d 3b 20 46 | 72 79 20 4c 0d 0a 28 52 |s CEM; F|ry L..(R|
|000009b0| 6f 79 61 6c 20 50 6f 73 | 74 67 72 61 64 75 61 74 |oyal Pos|tgraduat|
|000009c0| 65 20 4d 65 64 20 53 63 | 68 6f 6f 6c 2c 20 4c 6f |e Med Sc|hool, Lo|
|000009d0| 6e 64 6f 6e 3b 20 53 74 | 20 4d 61 72 79 27 73 20 |ndon; St| Mary's |
|000009e0| 48 6f 73 70 2c 20 4c 6f | 6e 64 6f 6e 29 0d 0a 42 |Hosp, Lo|ndon)..B|
|000009f0| 72 20 4a 20 44 65 72 6d | 61 74 6f 6c 20 31 31 38 |r J Derm|atol 118|
|00000a00| 3a 33 37 37 2d 33 38 33 | 2c 20 4d 61 72 63 68 20 |:377-383|, March |
|00000a10| 31 39 38 38 0d 0a 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |1988..--|--------|
|00000a20| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000a30| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000a40| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000a50| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000a60| 2d 2d 2d 2d 2d 2d 0d 0a | 0d 0a 41 62 73 74 72 61 |------..|..Abstra|
|00000a70| 63 74 0d 0a 0d 0a 20 20 | 20 20 20 54 68 65 20 65 |ct.... | The e|
|00000a80| 78 61 63 74 20 70 72 65 | 76 61 6c 65 6e 63 65 20 |xact pre|valence |
|00000a90| 6f 66 20 74 68 79 72 6f | 69 64 20 61 75 74 6f 61 |of thyro|id autoa|
|00000aa0| 6e 74 69 62 6f 64 69 65 | 73 20 69 6e 20 64 65 72 |ntibodie|s in der|
|00000ab0| 6d 61 74 69 74 69 73 20 | 68 65 72 70 65 74 69 66 |matitis |herpetif|
|00000ac0| 6f 72 6d 69 73 0d 0a 28 | 44 48 29 20 68 61 73 20 |ormis..(|DH) has |
|00000ad0| 6e 6f 74 20 62 65 65 6e | 20 65 73 74 61 62 6c 69 |not been| establi|
|00000ae0| 73 68 65 64 2e 20 20 54 | 6f 20 69 6e 76 65 73 74 |shed. T|o invest|
|00000af0| 69 67 61 74 65 20 74 68 | 69 73 20 72 65 6c 61 74 |igate th|is relat|
|00000b00| 69 6f 6e 73 68 69 70 2c | 20 31 31 35 20 70 61 74 |ionship,| 115 pat|
|00000b10| 69 65 6e 74 73 0d 0a 77 | 69 74 68 20 44 48 20 77 |ients..w|ith DH w|
|00000b20| 65 72 65 20 74 65 73 74 | 65 64 2c 20 77 69 74 68 |ere test|ed, with|
|00000b30| 20 74 68 65 20 75 73 65 | 20 6f 66 20 73 70 65 63 | the use| of spec|
|00000b40| 69 66 69 63 20 61 6e 64 | 20 73 65 6e 73 69 74 69 |ific and| sensiti|
|00000b50| 76 65 20 65 6e 7a 79 6d | 65 2d 6c 69 6e 6b 65 64 |ve enzym|e-linked|
|00000b60| 0d 0a 69 6d 6d 75 6e 6f | 73 6f 72 62 65 6e 74 20 |..immuno|sorbent |
|00000b70| 61 73 73 61 79 73 2c 20 | 66 6f 72 20 74 68 79 72 |assays, |for thyr|
|00000b80| 6f 67 6c 6f 62 75 6c 69 | 6e 20 61 6e 64 20 6d 69 |oglobuli|n and mi|
|00000b90| 63 72 6f 73 6f 6d 61 6c | 20 61 6e 74 69 62 6f 64 |crosomal| antibod|
|00000ba0| 69 65 73 20 61 6e 64 20 | 66 6f 72 0d 0a 74 68 79 |ies and |for..thy|
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|00000bd0| 65 73 75 6c 74 73 20 77 | 65 72 65 20 63 6f 6d 70 |esults w|ere comp|
|00000be0| 61 72 65 64 20 77 69 74 | 68 20 74 68 6f 73 65 20 |ared wit|h those |
|00000bf0| 6f 62 74 61 69 6e 65 64 | 20 69 6e 0d 0a 31 30 37 |obtained| in..107|
|00000c00| 20 75 6e 73 65 6c 65 63 | 74 65 64 20 63 6f 6e 74 | unselec|ted cont|
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|00000c20| 0d 0a 20 20 20 20 20 54 | 68 65 20 70 72 65 76 61 |.. T|he preva|
|00000c30| 6c 65 6e 63 65 20 6f 66 | 20 69 6d 6d 75 6e 6f 67 |lence of| immunog|
|00000c40| 6c 6f 62 75 6c 69 6e 20 | 47 20 28 49 67 47 29 20 |lobulin |G (IgG) |
|00000c50| 63 6c 61 73 73 20 74 68 | 79 72 6f 69 64 20 61 75 |class th|yroid au|
|00000c60| 74 6f 61 6e 74 69 62 6f | 64 69 65 73 20 77 61 73 |toantibo|dies was|
|00000c70| 0d 0a 34 38 25 20 69 6e | 20 70 61 74 69 65 6e 74 |..48% in| patient|
|00000c80| 73 20 77 69 74 68 20 44 | 48 2c 20 77 68 69 63 68 |s with D|H, which|
|00000c90| 20 77 61 73 20 73 69 67 | 6e 69 66 69 63 61 6e 74 | was sig|nificant|
|00000ca0| 6c 79 20 67 72 65 61 74 | 65 72 20 74 68 61 6e 20 |ly great|er than |
|00000cb0| 74 68 65 20 31 36 25 20 | 70 72 65 76 61 6c 65 6e |the 16% |prevalen|
|00000cc0| 63 65 0d 0a 69 6e 20 63 | 6f 6e 74 72 6f 6c 73 2e |ce..in c|ontrols.|
|00000cd0| 20 20 49 6d 6d 75 6e 6f | 67 6c 6f 62 75 6c 69 6e | Immuno|globulin|
|00000ce0| 20 41 20 63 6c 61 73 73 | 20 74 68 79 72 6f 69 64 | A class| thyroid|
|00000cf0| 20 61 6e 74 69 62 6f 64 | 69 65 73 20 77 65 72 65 | antibod|ies were|
|00000d00| 20 6e 6f 74 65 64 20 69 | 6e 20 32 39 25 20 6f 66 | noted i|n 29% of|
|00000d10| 20 44 48 0d 0a 70 61 74 | 69 65 6e 74 73 3b 20 34 | DH..pat|ients; 4|
|00000d20| 30 25 20 6f 66 20 74 68 | 65 20 70 61 74 69 65 6e |0% of th|e patien|
|00000d30| 74 73 20 77 68 6f 20 77 | 65 72 65 20 70 6f 73 69 |ts who w|ere posi|
|00000d40| 74 69 76 65 20 66 6f 72 | 20 49 67 47 20 63 6c 61 |tive for| IgG cla|
|00000d50| 73 73 20 61 6e 74 69 62 | 6f 64 79 20 61 6c 73 6f |ss antib|ody also|
|00000d60| 20 68 61 64 0d 0a 69 6d | 6d 75 6e 6f 67 6c 6f 62 | had..im|munoglob|
|00000d70| 75 6c 69 6e 20 41 20 63 | 6c 61 73 73 20 61 6e 74 |ulin A c|lass ant|
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|00000df0| 20 77 68 69 6c 65 20 61 | 6e 6f 74 68 65 72 20 36 | while a|nother 6|
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|00000ed0| 20 54 68 65 72 65 20 77 | 61 73 20 6e 6f 20 73 69 | There w|as no si|
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|00000ef0| 61 74 69 6f 6e 0d 0a 6f | 66 20 61 6e 79 20 48 4c |ation..o|f any HL|
|00000f00| 41 2d 44 52 20 61 6e 74 | 69 67 65 6e 20 77 69 74 |A-DR ant|igen wit|
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|00000f30| 74 69 62 6f 64 69 65 73 | 2e 0d 0a 20 20 20 20 20 |tibodies|... |
|00000f40| 54 68 69 73 20 73 74 75 | 64 79 20 73 68 6f 77 65 |This stu|dy showe|
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|00000f90| 20 44 48 2e 20 20 49 74 | 20 61 70 70 65 61 72 73 | DH. It| appears|
|00000fa0| 20 74 68 61 74 20 61 6e | 20 69 6d 6d 75 6e 65 20 | that an| immune |
|00000fb0| 72 65 73 70 6f 6e 73 65 | 20 67 65 6e 65 20 6f 75 |response| gene ou|
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|00000fd0| 0d 0a 72 65 67 69 6f 6e | 20 6d 61 79 20 62 65 20 |..region| may be |
|00000fe0| 69 6e 76 6f 6c 76 65 64 | 20 69 6e 20 74 68 65 20 |involved| in the |
|00000ff0| 69 6d 6d 75 6e 65 20 68 | 79 70 65 72 72 65 73 70 |immune h|yperresp|
|00001000| 6f 6e 73 69 76 65 6e 65 | 73 73 20 69 6e 20 44 48 |onsivene|ss in DH|
|00001010| 2c 20 61 73 20 72 65 66 | 6c 65 63 74 65 64 20 62 |, as ref|lected b|
|00001020| 79 0d 0a 74 68 65 20 68 | 69 67 68 20 70 72 65 76 |y..the h|igh prev|
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|00001040| 64 20 61 75 74 6f 69 6d | 6d 75 6e 69 74 79 2e 0d |d autoim|munity..|
|00001050| 0a 0d 0a 50 6f 73 74 2d | 43 6f 6d 6d 65 6e 74 0d |...Post-|Comment.|
|00001060| 0a 0d 0a 20 20 20 20 20 | 54 68 65 72 65 20 69 73 |... |There is|
|00001070| 20 61 20 67 65 6e 65 72 | 61 6c 69 7a 65 64 20 69 | a gener|alized i|
|00001080| 6d 6d 75 6e 65 20 68 79 | 70 65 72 61 63 74 69 76 |mmune hy|peractiv|
|00001090| 69 74 79 20 69 6e 20 44 | 48 2c 20 77 69 74 68 20 |ity in D|H, with |
|000010a0| 61 75 74 6f 61 6e 74 69 | 62 6f 64 69 65 73 0d 0a |autoanti|bodies..|
|000010b0| 61 67 61 69 6e 73 74 20 | 72 65 74 69 63 75 6c 69 |against |reticuli|
|000010c0| 6e 2c 20 67 61 73 74 72 | 69 63 20 70 61 72 69 65 |n, gastr|ic parie|
|000010d0| 74 61 6c 20 63 65 6c 6c | 73 2c 20 74 68 79 72 6f |tal cell|s, thyro|
|000010e0| 69 64 20 61 6e 74 69 67 | 65 6e 73 2c 20 61 6e 64 |id antig|ens, and|
|000010f0| 20 61 6e 74 69 6e 75 63 | 6c 65 61 72 0d 0a 61 6e | antinuc|lear..an|
|00001100| 74 69 62 6f 64 69 65 73 | 2e 20 20 54 68 65 20 61 |tibodies|. The a|
|00001110| 75 74 68 6f 72 73 20 66 | 6f 75 6e 64 20 49 67 47 |uthors f|ound IgG|
|00001120| 20 63 6c 61 73 73 20 74 | 68 79 72 6f 67 6c 6f 62 | class t|hyroglob|
|00001130| 75 6c 69 6e 20 61 6e 64 | 20 6d 69 63 72 6f 73 6f |ulin and| microso|
|00001140| 6d 61 6c 0d 0a 61 6e 74 | 69 62 6f 64 69 65 73 2c |mal..ant|ibodies,|
|00001150| 20 75 73 69 6e 67 20 61 | 20 73 65 6e 73 69 74 69 | using a| sensiti|
|00001160| 76 65 20 45 4c 49 53 41 | 2c 20 69 6e 20 34 38 25 |ve ELISA|, in 48%|
|00001170| 20 6f 66 20 31 31 35 20 | 70 61 74 69 65 6e 74 73 | of 115 |patients|
|00001180| 20 77 69 74 68 20 44 48 | 2c 20 63 6f 6d 70 61 72 | with DH|, compar|
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|000011a0| 6c 65 6e 63 65 20 6f 66 | 20 31 36 25 20 69 6e 20 |lence of| 16% in |
|000011b0| 31 30 37 20 63 6f 6e 74 | 72 6f 6c 73 2e 20 20 41 |107 cont|rols. A|
|000011c0| 64 64 69 74 69 6f 6e 61 | 6c 6c 79 2c 20 32 39 25 |dditiona|lly, 29%|
|000011d0| 20 6f 66 20 44 48 20 70 | 61 74 69 65 6e 74 73 20 | of DH p|atients |
|000011e0| 68 61 64 0d 0a 49 67 41 | 20 63 6c 61 73 73 20 74 |had..IgA| class t|
|000011f0| 68 79 72 6f 69 64 20 61 | 6e 74 69 62 6f 64 69 65 |hyroid a|ntibodie|
|00001200| 73 2e 20 20 54 68 79 72 | 6f 69 64 20 64 69 73 65 |s. Thyr|oid dise|
|00001210| 61 73 65 20 77 61 73 20 | 64 69 61 67 6e 6f 73 65 |ase was |diagnose|
|00001220| 64 20 69 6e 20 6f 6e 6c | 79 20 35 25 20 28 36 0d |d in onl|y 5% (6.|
|00001230| 0a 70 61 74 69 65 6e 74 | 73 29 20 6f 66 20 74 68 |.patient|s) of th|
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|00001260| 61 74 69 6f 6e 20 6f 66 | 20 74 68 79 72 6f 69 64 |ation of| thyroid|
|00001270| 20 61 6e 74 69 62 6f 64 | 69 65 73 20 77 69 74 68 | antibod|ies with|
|00001280| 0d 0a 61 20 70 61 72 74 | 69 63 75 6c 61 72 20 48 |..a part|icular H|
|00001290| 4c 41 2d 44 52 20 61 6e | 74 69 67 65 6e 2e 2d 2d |LA-DR an|tigen.--|
|000012a0| 52 2e 20 4d 61 73 74 65 | 72 73 2c 20 4d 2e 44 2e |R. Maste|rs, M.D.|
|000012b0| 0d 0a 24 55 6e 69 71 75 | 65 5f 49 44 7b 59 52 42 |..$Uniqu|e_ID{YRB|
|000012c0| 30 34 38 30 31 7d 0d 0a | 24 54 69 74 6c 65 7b 49 |04801}..|$Title{I|
|000012d0| 6d 6d 75 6e 6f 67 6c 6f | 62 75 6c 69 6e 20 41 20 |mmunoglo|bulin A |
|000012e0| 44 65 70 6f 73 69 74 69 | 6f 6e 20 69 6e 20 4a 65 |Depositi|on in Je|
|000012f0| 6a 75 6e 61 6c 20 4d 75 | 63 6f 73 61 20 6f 66 20 |junal Mu|cosa of |
|00001300| 43 68 69 6c 64 72 65 6e | 20 57 69 74 68 20 44 65 |Children| With De|
|00001310| 72 6d 61 74 69 74 69 73 | 20 48 65 72 70 65 74 69 |rmatitis| Herpeti|
|00001320| 66 6f 72 6d 69 73 7d 0d | 0a 24 41 75 74 68 6f 72 |formis}.|.$Author|
|00001330| 7b 0d 0a 4b 61 72 70 61 | 74 69 2c 20 53 0d 0a 4b |{..Karpa|ti, S..K|
|00001340| 6f 73 6e 61 69 2c 20 49 | 0d 0a 54 6f 72 6f 6b 2c |osnai, I|..Torok,|
|00001350| 20 45 0d 0a 4b 6f 76 61 | 63 73 2c 20 4a 42 7d 0d | E..Kova|cs, JB}.|
|00001360| 0a 24 41 66 66 69 6c 69 | 61 74 69 6f 6e 7b 43 68 |.$Affili|ation{Ch|
|00001370| 69 6c 64 72 65 6e 27 73 | 20 48 6f 73 70 20 48 65 |ildren's| Hosp He|
|00001380| 69 6d 20 50 61 6c 2c 20 | 42 75 64 61 70 65 73 74 |im Pal, |Budapest|
|00001390| 3b 20 53 65 6d 6d 65 6c | 77 65 69 73 20 55 6e 69 |; Semmel|weis Uni|
|000013a0| 76 2c 20 42 75 64 61 70 | 65 73 74 7d 0d 0a 24 53 |v, Budap|est}..$S|
|000013b0| 75 62 6a 65 63 74 7b 4a | 65 6a 75 6e 61 6c 20 6d |ubject{J|ejunal m|
|000013c0| 75 63 6f 73 61 2c 20 49 | 67 41 20 64 65 70 6f 73 |ucosa, I|gA depos|
|000013d0| 69 74 69 6f 6e 20 69 6e | 2c 20 69 6e 20 64 65 72 |ition in|, in der|
|000013e0| 6d 61 74 69 74 69 73 20 | 68 65 72 70 65 74 69 66 |matitis |herpetif|
|000013f0| 6f 72 6d 69 73 20 69 6e | 20 63 68 69 6c 64 72 65 |ormis in| childre|
|00001400| 6e 3b 0d 0a 44 65 72 6d | 61 74 69 74 69 73 20 68 |n;..Derm|atitis h|
|00001410| 65 72 70 65 74 69 66 6f | 72 6d 69 73 20 49 67 41 |erpetifo|rmis IgA|
|00001420| 20 64 65 70 6f 73 69 74 | 69 6f 6e 20 69 6e 20 6a | deposit|ion in j|
|00001430| 65 6a 75 6e 61 6c 20 6d | 75 63 6f 73 61 20 69 6e |ejunal m|ucosa in|
|00001440| 20 63 68 69 6c 64 72 65 | 6e 3b 0d 0a 43 68 69 6c | childre|n;..Chil|
|00001450| 64 72 65 6e 20 64 65 72 | 6d 61 74 69 74 69 73 20 |dren der|matitis |
|00001460| 68 65 72 70 65 74 69 66 | 6f 72 6d 69 73 2c 20 49 |herpetif|ormis, I|
|00001470| 67 41 20 64 65 70 6f 73 | 69 74 69 6f 6e 20 69 6e |gA depos|ition in|
|00001480| 20 6a 65 6a 75 6e 61 6c | 20 6d 75 63 6f 73 61 20 | jejunal| mucosa |
|00001490| 69 6e 20 20 64 65 72 6d | 61 74 69 74 69 73 20 68 |in derm|atitis h|
|000014a0| 65 72 70 65 74 69 66 6f | 72 6d 69 73 2c 20 49 67 |erpetifo|rmis, Ig|
|000014b0| 41 20 64 65 70 6f 73 69 | 74 69 6f 6e 20 69 6e 20 |A deposi|tion in |
|000014c0| 6a 65 6a 75 6e 61 6c 20 | 6d 75 63 6f 73 61 20 69 |jejunal |mucosa i|
|000014d0| 6e 7d 0d 0a 24 4a 6f 75 | 72 6e 61 6c 7b 4a 20 49 |n}..$Jou|rnal{J I|
|000014e0| 6e 76 65 73 74 20 44 65 | 72 6d 61 74 6f 6c 7d 0d |nvest De|rmatol}.|
|000014f0| 0a 24 56 6f 6c 75 6d 65 | 7b 39 31 7d 0d 0a 24 50 |.$Volume|{91}..$P|
|00001500| 61 67 65 7b 33 33 36 2d | 33 33 39 7d 0d 0a 24 44 |age{336-|339}..$D|
|00001510| 61 74 65 7b 4f 63 74 6f | 62 65 72 20 31 39 38 38 |ate{Octo|ber 1988|
|00001520| 7d 0d 0a 24 59 42 56 6f | 6c 7b 31 39 38 39 20 59 |}..$YBVo|l{1989 Y|
|00001530| 65 61 72 20 42 6f 6f 6b | 20 6f 66 20 44 65 72 6d |ear Book| of Derm|
|00001540| 61 74 6f 6c 6f 67 79 7d | 0d 0a 24 43 68 61 70 74 |atology}|..$Chapt|
|00001550| 65 72 7b 33 2d 31 37 7d | 0d 0a 24 59 42 45 64 69 |er{3-17}|..$YBEdi|
|00001560| 74 6f 72 7b 44 72 73 2e | 20 53 6f 62 65 72 20 61 |tor{Drs.| Sober a|
|00001570| 6e 64 20 46 69 74 7a 70 | 61 74 72 69 63 6b 7d 0d |nd Fitzp|atrick}.|
|00001580| 0a 24 54 61 62 6c 65 7b | 54 61 62 6c 65 20 4f 6d |.$Table{|Table Om|
|00001590| 69 74 74 65 64 7d 0d 0a | 24 43 6f 6d 6d 65 6e 74 |itted}..|$Comment|
|000015a0| 61 74 6f 72 7b 52 2e 20 | 4d 61 73 74 65 72 73 2c |ator{R. |Masters,|
|000015b0| 20 4d 2e 44 2e 7d 0d 0a | 0d 0a 43 6f 70 79 72 69 | M.D.}..|..Copyri|
|000015c0| 67 68 74 20 28 63 29 20 | 59 65 61 72 20 42 6f 6f |ght (c) |Year Boo|
|000015d0| 6b 20 4d 65 64 69 63 61 | 6c 20 50 75 62 6c 69 73 |k Medica|l Publis|
|000015e0| 68 65 72 73 2c 20 49 6e | 63 2e 2c 20 31 39 38 39 |hers, In|c., 1989|
|000015f0| 0d 0a 0d 0a 31 39 38 39 | 20 59 65 61 72 20 42 6f |....1989| Year Bo|
|00001600| 6f 6b 20 6f 66 20 44 65 | 72 6d 61 74 6f 6c 6f 67 |ok of De|rmatolog|
|00001610| 79 20 28 52 29 0d 0a 0d | 0a 43 68 61 70 74 65 72 |y (R)...|.Chapter|
|00001620| 20 33 2d 2d 42 75 6c 6c | 6f 75 73 20 44 69 73 65 | 3--Bull|ous Dise|
|00001630| 61 73 65 73 0d 0a 0d 0a | 2d 2d 2d 2d 2d 2d 2d 2d |ases....|--------|
|00001640| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00001650| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00001660| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00001670| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00001680| 2d 2d 2d 2d 2d 2d 2d 2d | 0d 0a 49 6d 6d 75 6e 6f |--------|..Immuno|
|00001690| 67 6c 6f 62 75 6c 69 6e | 20 41 20 44 65 70 6f 73 |globulin| A Depos|
|000016a0| 69 74 69 6f 6e 20 69 6e | 20 4a 65 6a 75 6e 61 6c |ition in| Jejunal|
|000016b0| 20 4d 75 63 6f 73 61 20 | 6f 66 20 43 68 69 6c 64 | Mucosa |of Child|
|000016c0| 72 65 6e 20 57 69 74 68 | 20 44 65 72 6d 61 74 69 |ren With| Dermati|
|000016d0| 74 69 73 0d 0a 48 65 72 | 70 65 74 69 66 6f 72 6d |tis..Her|petiform|
|000016e0| 69 73 0d 0a 0d 0a 4b 61 | 72 70 61 74 69 20 53 3b |is....Ka|rpati S;|
|000016f0| 20 4b 6f 73 6e 61 69 20 | 49 3b 20 54 6f 72 6f 6b | Kosnai |I; Torok|
|00001700| 20 45 3b 20 4b 6f 76 61 | 63 73 20 4a 42 0d 0a 28 | E; Kova|cs JB..(|
|00001710| 43 68 69 6c 64 72 65 6e | 27 73 20 48 6f 73 70 20 |Children|'s Hosp |
|00001720| 48 65 69 6d 20 50 61 6c | 2c 20 42 75 64 61 70 65 |Heim Pal|, Budape|
|00001730| 73 74 3b 20 53 65 6d 6d | 65 6c 77 65 69 73 20 55 |st; Semm|elweis U|
|00001740| 6e 69 76 2c 20 42 75 64 | 61 70 65 73 74 29 0d 0a |niv, Bud|apest)..|
|00001750| 4a 20 49 6e 76 65 73 74 | 20 44 65 72 6d 61 74 6f |J Invest| Dermato|
|00001760| 6c 20 39 31 3a 33 33 36 | 2d 33 33 39 2c 20 4f 63 |l 91:336|-339, Oc|
|00001770| 74 6f 62 65 72 20 31 39 | 38 38 0d 0a 2d 2d 2d 2d |tober 19|88..----|
|00001780| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00001790| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000017a0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000017b0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000017c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 0d 0a 0d 0a |--------|----....|
|000017d0| 41 62 73 74 72 61 63 74 | 0d 0a 0d 0a 20 20 20 20 |Abstract|.... |
|000017e0| 20 41 20 73 70 65 63 69 | 61 6c 20 69 6d 6d 75 6e | A speci|al immun|
|000017f0| 6f 67 6c 6f 62 75 6c 69 | 6e 20 41 20 28 49 67 41 |oglobuli|n A (IgA|
|00001800| 29 20 61 6e 74 69 6a 65 | 6a 75 6e 61 6c 20 61 6e |) antije|junal an|
|00001810| 74 69 62 6f 64 79 20 69 | 6e 20 74 68 65 20 73 65 |tibody i|n the se|
|00001820| 72 61 20 6f 66 0d 0a 63 | 68 69 6c 64 72 65 6e 20 |ra of..c|hildren |
|00001830| 77 69 74 68 20 64 65 72 | 6d 61 74 69 74 69 73 20 |with der|matitis |
|00001840| 68 65 72 70 65 74 69 66 | 6f 72 6d 69 73 20 68 61 |herpetif|ormis ha|
|00001850| 73 20 62 65 65 6e 20 6f | 62 73 65 72 76 65 64 2e |s been o|bserved.|
|00001860| 20 20 49 74 20 69 73 20 | 62 6f 75 6e 64 20 74 6f | It is |bound to|
|00001870| 20 6e 6f 72 6d 61 6c 0d | 0a 6a 65 6a 75 6e 75 6d | normal.|.jejunum|
|00001880| 20 62 65 6e 65 61 74 68 | 20 74 68 65 20 76 69 6c | beneath| the vil|
|00001890| 6c 6f 75 73 20 61 6e 64 | 20 63 72 79 70 74 20 65 |lous and| crypt e|
|000018a0| 70 69 74 68 65 6c 69 61 | 6c 20 62 61 73 65 6d 65 |pithelia|l baseme|
|000018b0| 6e 74 20 6d 65 6d 62 72 | 61 6e 65 73 2c 20 74 68 |nt membr|anes, th|
|000018c0| 65 20 6c 61 6d 69 6e 61 | 0d 0a 70 72 6f 70 72 69 |e lamina|..propri|
|000018d0| 61 20 6e 65 78 74 20 74 | 6f 20 61 20 74 75 62 75 |a next t|o a tubu|
|000018e0| 6c 61 72 2c 20 70 6f 73 | 73 69 62 6c 79 20 63 61 |lar, pos|sibly ca|
|000018f0| 70 69 6c 6c 61 72 79 20 | 73 79 73 74 65 6d 2c 20 |pillary |system, |
|00001900| 61 6e 64 20 61 6c 6f 6e | 67 20 62 6c 6f 6f 64 20 |and alon|g blood |
|00001910| 76 65 73 73 65 6c 73 0d | 0a 61 6e 64 20 74 68 65 |vessels.|.and the|
|00001920| 20 73 61 72 63 6f 6c 65 | 6d 6d 61 20 6f 66 20 74 | sarcole|mma of t|
|00001930| 68 65 20 73 6d 6f 6f 74 | 68 20 6d 75 73 63 6c 65 |he smoot|h muscle|
|00001940| 20 6c 61 79 65 72 2e 20 | 20 54 68 65 20 64 65 70 | layer. | The dep|
|00001950| 6f 73 69 74 69 6f 6e 20 | 6f 66 0d 0a 69 6d 6d 75 |osition |of..immu|
|00001960| 6e 6f 67 6c 6f 62 75 6c | 69 6e 73 20 69 6e 20 74 |noglobul|ins in t|
|00001970| 68 65 20 6a 65 6a 75 6e | 75 6d 20 6f 66 20 63 68 |he jejun|um of ch|
|00001980| 69 6c 64 72 65 6e 20 77 | 69 74 68 20 64 65 72 6d |ildren w|ith derm|
|00001990| 61 74 69 74 69 73 20 68 | 65 72 70 65 74 69 66 6f |atitis h|erpetifo|
|000019a0| 72 6d 69 73 20 62 65 66 | 6f 72 65 0d 0a 61 6e 64 |rmis bef|ore..and|
|000019b0| 20 61 66 74 65 72 20 61 | 20 67 6c 75 74 65 6e 2d | after a| gluten-|
|000019c0| 66 72 65 65 20 64 69 65 | 74 20 28 47 46 44 29 20 |free die|t (GFD) |
|000019d0| 61 6e 64 20 75 6e 64 65 | 72 20 67 6c 75 74 65 6e |and unde|r gluten|
|000019e0| 20 63 68 61 6c 6c 65 6e | 67 65 20 77 61 73 20 73 | challen|ge was s|
|000019f0| 74 75 64 69 65 64 2e 0d | 0a 20 20 20 20 20 4e 69 |tudied..|. Ni|
|00001a00| 6e 65 20 67 69 72 6c 73 | 20 61 6e 64 20 36 20 62 |ne girls| and 6 b|
|00001a10| 6f 79 73 20 77 69 74 68 | 20 64 65 72 6d 61 74 69 |oys with| dermati|
|00001a20| 74 69 73 20 68 65 72 70 | 65 74 69 66 6f 72 6d 69 |tis herp|etiformi|
|00001a30| 73 2c 20 61 67 65 64 20 | 32 20 74 6f 20 31 35 20 |s, aged |2 to 15 |
|00001a40| 79 65 61 72 73 2c 0d 0a | 70 61 72 74 69 63 69 70 |years,..|particip|
|00001a50| 61 74 65 64 2e 20 20 41 | 6e 6f 74 68 65 72 20 67 |ated. A|nother g|
|00001a60| 72 6f 75 70 20 6f 66 20 | 63 68 69 6c 64 72 65 6e |roup of |children|
|00001a70| 73 20 73 65 72 76 65 64 | 20 61 73 20 63 6f 6e 74 |s served| as cont|
|00001a80| 72 6f 6c 73 2e 20 20 44 | 69 72 65 63 74 0d 0a 69 |rols. D|irect..i|
|00001a90| 6d 6d 75 6e 6f 66 6c 75 | 6f 72 65 73 63 65 6e 63 |mmunoflu|orescenc|
|00001aa0| 65 20 73 74 75 64 69 65 | 73 20 73 68 6f 77 65 64 |e studie|s showed|
|00001ab0| 20 74 68 61 74 20 73 70 | 65 63 69 66 69 63 20 49 | that sp|ecific I|
|00001ac0| 67 41 20 64 65 70 6f 73 | 69 74 73 20 77 65 72 65 |gA depos|its were|
|00001ad0| 20 70 72 65 73 65 6e 74 | 20 69 6e 20 74 68 65 0d | present| in the.|
|00001ae0| 0a 70 72 6f 78 69 6d 61 | 6c 20 6a 65 6a 75 6e 75 |.proxima|l jejunu|
|00001af0| 6d 20 6f 66 20 31 31 20 | 6f 66 20 31 32 20 70 61 |m of 11 |of 12 pa|
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|000028b0| 69 64 65 72 6d 0d 0a 61 | 6c 6c 6f 77 73 20 70 65 |iderm..a|llows pe|
|000028c0| 6e 65 74 72 61 74 69 6f | 6e 20 6f 66 20 6c 6f 63 |netratio|n of loc|
|000028d0| 61 6c 20 61 6e 74 69 62 | 69 6f 74 69 63 73 2e 20 |al antib|iotics. |
|000028e0| 20 54 68 65 20 62 61 62 | 79 20 77 61 73 20 61 6c | The bab|y was al|
|000028f0| 73 6f 20 74 72 65 61 74 | 65 64 20 77 69 74 68 0d |so treat|ed with.|
|00002900| 0a 68 79 64 61 6e 74 6f | 69 6e 2c 20 77 68 69 63 |.hydanto|in, whic|
|00002910| 68 20 73 75 70 70 6f 73 | 65 64 6c 79 20 64 65 63 |h suppos|edly dec|
|00002920| 72 65 61 73 65 73 20 74 | 68 65 20 68 69 67 68 20 |reases t|he high |
|00002930| 6c 65 76 65 6c 73 20 6f | 66 20 63 6f 6c 6c 61 67 |levels o|f collag|
|00002940| 65 6e 61 73 65 0d 0a 63 | 68 61 72 61 63 74 65 72 |enase..c|haracter|
|00002950| 69 73 74 69 63 20 6f 66 | 20 74 68 69 73 20 64 69 |istic of| this di|
|00002960| 73 6f 72 64 65 72 2e 20 | 20 41 74 20 31 20 79 65 |sorder. | At 1 ye|
|00002970| 61 72 20 6f 66 20 61 67 | 65 2c 20 74 68 65 20 62 |ar of ag|e, the b|
|00002980| 61 62 79 20 68 61 64 20 | 6e 6f 20 73 6b 69 6e 0d |aby had |no skin.|
|00002990| 0a 64 65 66 65 63 74 73 | 3b 20 68 79 64 61 6e 74 |.defects|; hydant|
|000029a0| 6f 69 6e 20 74 72 65 61 | 74 6d 65 6e 74 20 68 61 |oin trea|tment ha|
|000029b0| 64 20 6e 6f 74 20 79 65 | 74 20 62 65 65 6e 20 64 |d not ye|t been d|
|000029c0| 69 73 63 6f 6e 74 69 6e | 75 65 64 2e 0d 0a 0d 0a |iscontin|ued.....|
|000029d0| 50 6f 73 74 2d 43 6f 6d | 6d 65 6e 74 0d 0a 0d 0a |Post-Com|ment....|
|000029e0| 20 20 20 20 20 48 6f 77 | 20 77 61 73 20 74 68 65 | How| was the|
|000029f0| 20 64 69 61 67 6e 6f 73 | 69 73 20 6f 66 20 65 70 | diagnos|is of ep|
|00002a00| 69 64 65 72 6d 6f 6c 79 | 73 69 73 20 62 75 6c 6c |idermoly|sis bull|
|00002a10| 6f 73 61 20 6d 61 64 65 | 3f 20 20 49 20 68 61 76 |osa made|? I hav|
|00002a20| 65 20 73 65 65 6e 20 69 | 6e 66 61 6e 74 73 0d 0a |e seen i|nfants..|
|00002a30| 77 69 74 68 20 64 65 6e | 75 64 61 74 69 6f 6e 20 |with den|udation |
|00002a40| 73 69 6d 69 6c 61 72 20 | 74 6f 20 74 68 61 74 20 |similar |to that |
|00002a50| 69 6e 20 74 68 65 20 70 | 68 6f 74 6f 73 20 6f 66 |in the p|hotos of|
|00002a60| 20 74 68 69 73 20 61 72 | 74 69 63 6c 65 20 63 61 | this ar|ticle ca|
|00002a70| 75 73 65 64 20 62 79 0d | 0a 74 72 61 6e 73 69 65 |used by.|.transie|
|00002a80| 6e 74 2c 20 69 6e 20 75 | 74 65 72 6f 20 70 72 6f |nt, in u|tero pro|
|00002a90| 62 6c 65 6d 73 20 28 61 | 70 6c 61 73 69 61 20 63 |blems (a|plasia c|
|00002aa0| 75 74 69 73 20 63 6f 6e | 67 65 6e 69 74 61 2c 20 |utis con|genita, |
|00002ab0| 53 74 72 65 65 74 65 72 | 27 73 20 62 61 6e 64 73 |Streeter|'s bands|
|00002ac0| 29 2e 20 20 49 66 0d 0a | 74 68 69 73 20 77 61 73 |). If..|this was|
|00002ad0| 20 65 70 69 64 65 72 6d | 6f 6c 79 73 69 73 20 62 | epiderm|olysis b|
|00002ae0| 75 6c 6c 6f 73 61 2c 20 | 69 74 20 6c 6f 6f 6b 73 |ullosa, |it looks|
|00002af0| 20 6c 69 6b 65 20 74 68 | 65 20 73 69 6d 70 6c 65 | like th|e simple|
|00002b00| 78 20 76 61 72 69 65 74 | 79 2e 20 20 42 75 74 0d |x variet|y. But.|
|00002b10| 0a 68 79 64 61 6e 74 6f | 69 6e 20 77 61 73 20 75 |.hydanto|in was u|
|00002b20| 73 65 64 20 68 65 72 65 | 2c 20 77 68 69 63 68 20 |sed here|, which |
|00002b30| 69 73 20 73 70 65 63 69 | 66 69 63 20 66 6f 72 20 |is speci|fic for |
|00002b40| 74 68 65 20 72 65 63 65 | 73 73 69 76 65 20 64 79 |the rece|ssive dy|
|00002b50| 73 74 72 6f 70 68 69 63 | 20 74 79 70 65 2e 0d 0a |strophic| type...|
|00002b60| 48 6f 77 20 63 61 6e 20 | 77 65 20 73 65 70 61 72 |How can |we separ|
|00002b70| 61 74 65 20 6f 75 74 20 | 74 68 65 20 65 66 66 65 |ate out |the effe|
|00002b80| 63 74 20 6f 66 20 74 68 | 65 20 77 6f 75 6e 64 20 |ct of th|e wound |
|00002b90| 63 6f 76 65 72 69 6e 67 | 20 66 72 6f 6d 20 74 68 |covering| from th|
|00002ba0| 65 20 65 66 66 65 63 74 | 20 6f 66 20 74 68 65 0d |e effect| of the.|
|00002bb0| 0a 64 72 75 67 20 69 66 | 20 69 74 20 64 69 64 20 |.drug if| it did |
|00002bc0| 77 6f 72 6b 3f 20 20 49 | 74 27 73 20 6e 6f 74 20 |work? I|t's not |
|00002bd0| 6b 6f 73 68 65 72 20 74 | 6f 20 75 73 65 20 32 20 |kosher t|o use 2 |
|00002be0| 6d 6f 64 61 6c 69 74 69 | 65 73 20 6f 66 20 74 68 |modaliti|es of th|
|00002bf0| 65 72 61 70 79 20 61 6e | 64 20 63 6c 61 69 6d 0d |erapy an|d claim.|
|00002c00| 0a 74 68 61 74 20 31 20 | 6f 66 20 74 68 65 6d 20 |.that 1 |of them |
|00002c10| 77 61 73 20 65 66 66 65 | 63 74 69 76 65 2e 20 20 |was effe|ctive. |
|00002c20| 49 20 74 68 69 6e 6b 20 | 6d 6f 72 65 20 69 6e 76 |I think |more inv|
|00002c30| 65 73 74 69 67 61 74 69 | 6f 6e 20 69 73 20 77 61 |estigati|on is wa|
|00002c40| 72 72 61 6e 74 65 64 20 | 74 6f 0d 0a 64 65 74 65 |rranted |to..dete|
|00002c50| 72 6d 69 6e 65 20 77 68 | 65 74 68 65 72 20 4f 6d |rmine wh|ether Om|
|00002c60| 69 64 65 72 6d 20 69 73 | 20 61 6e 20 65 66 66 65 |iderm is| an effe|
|00002c70| 63 74 69 76 65 20 74 68 | 65 72 61 70 65 75 74 69 |ctive th|erapeuti|
|00002c80| 63 20 61 67 65 6e 74 20 | 66 6f 72 20 61 6e 79 20 |c agent |for any |
|00002c90| 74 79 70 65 20 6f 66 0d | 0a 65 70 69 64 65 72 6d |type of.|.epiderm|
|00002ca0| 6f 6c 79 73 69 73 20 62 | 75 6c 6c 6f 73 61 2e 2d |olysis b|ullosa.-|
|00002cb0| 2d 4a 2e 43 2e 20 41 6c | 70 65 72 2c 20 4d 2e 44 |-J.C. Al|per, M.D|
|00002cc0| 2e 0d 0a 24 55 6e 69 71 | 75 65 5f 49 44 7b 59 52 |...$Uniq|ue_ID{YR|
|00002cd0| 42 30 34 38 30 33 7d 0d | 0a 24 54 69 74 6c 65 7b |B04803}.|.$Title{|
|00002ce0| 45 76 61 6c 75 61 74 69 | 6f 6e 20 6f 66 20 74 68 |Evaluati|on of th|
|00002cf0| 65 20 45 66 66 69 63 61 | 63 79 20 6f 66 20 54 6f |e Effica|cy of To|
|00002d00| 70 69 63 61 6c 20 42 75 | 66 65 78 61 6d 61 63 20 |pical Bu|fexamac |
|00002d10| 69 6e 20 45 70 69 64 65 | 72 6d 6f 6c 79 73 69 73 |in Epide|rmolysis|
|00002d20| 20 42 75 6c 6c 6f 73 61 | 20 53 69 6d 70 6c 65 78 | Bullosa| Simplex|
|00002d30| 3a 20 20 41 20 44 6f 75 | 62 6c 65 2d 42 6c 69 6e |: A Dou|ble-Blin|
|00002d40| 64 20 50 6c 61 63 65 62 | 6f 2d 43 6f 6e 74 72 6f |d Placeb|o-Contro|
|00002d50| 6c 6c 65 64 20 43 72 6f | 73 73 6f 76 65 72 20 54 |lled Cro|ssover T|
|00002d60| 72 69 61 6c 7d 0d 0a 24 | 41 75 74 68 6f 72 7b 0d |rial}..$|Author{.|
|00002d70| 0a 46 69 6e 65 2c 20 4a | 2d 44 0d 0a 4a 6f 68 6e |.Fine, J|-D..John|
|00002d80| 73 6f 6e 2c 20 4c 7d 0d | 0a 24 41 66 66 69 6c 69 |son, L}.|.$Affili|
|00002d90| 61 74 69 6f 6e 7b 55 6e | 69 76 20 6f 66 20 41 6c |ation{Un|iv of Al|
|00002da0| 61 62 61 6d 61 20 69 6e | 20 42 69 72 6d 69 6e 67 |abama in| Birming|
|00002db0| 68 61 6d 3b 20 42 69 72 | 6d 69 6e 67 68 61 6d 20 |ham; Bir|mingham |
|00002dc0| 56 41 20 4d 65 64 20 43 | 74 72 7d 0d 0a 24 53 75 |VA Med C|tr}..$Su|
|00002dd0| 62 6a 65 63 74 7b 45 70 | 69 64 65 72 6d 6f 6c 79 |bject{Ep|idermoly|
|00002de0| 73 69 73 20 62 75 6c 6c | 6f 73 61 20 73 69 6d 70 |sis bull|osa simp|
|00002df0| 6c 65 78 2c 20 62 75 66 | 65 78 61 6d 61 63 20 69 |lex, buf|examac i|
|00002e00| 6e 3b 0d 0a 42 75 66 65 | 78 61 6d 61 63 20 69 6e |n;..Bufe|xamac in|
|00002e10| 20 65 70 69 64 65 72 6d | 6f 6c 79 73 69 73 20 62 | epiderm|olysis b|
|00002e20| 75 6c 6c 6f 73 61 20 73 | 69 6d 70 6c 65 78 7d 0d |ullosa s|implex}.|
|00002e30| 0a 24 4a 6f 75 72 6e 61 | 6c 7b 41 72 63 68 20 44 |.$Journa|l{Arch D|
|00002e40| 65 72 6d 61 74 6f 6c 7d | 0d 0a 24 56 6f 6c 75 6d |ermatol}|..$Volum|
|00002e50| 65 7b 31 32 34 7d 0d 0a | 24 50 61 67 65 7b 31 36 |e{124}..|$Page{16|
|00002e60| 36 39 2d 31 36 37 32 7d | 0d 0a 24 44 61 74 65 7b |69-1672}|..$Date{|
|00002e70| 4e 6f 76 65 6d 62 65 72 | 20 31 39 38 38 7d 0d 0a |November| 1988}..|
|00002e80| 24 59 42 56 6f 6c 7b 31 | 39 38 39 20 59 65 61 72 |$YBVol{1|989 Year|
|00002e90| 20 42 6f 6f 6b 20 6f 66 | 20 44 65 72 6d 61 74 6f | Book of| Dermato|
|00002ea0| 6c 6f 67 79 7d 0d 0a 24 | 43 68 61 70 74 65 72 7b |logy}..$|Chapter{|
|00002eb0| 33 2d 31 39 7d 0d 0a 24 | 59 42 45 64 69 74 6f 72 |3-19}..$|YBEditor|
|00002ec0| 7b 44 72 73 2e 20 53 6f | 62 65 72 20 61 6e 64 20 |{Drs. So|ber and |
|00002ed0| 46 69 74 7a 70 61 74 72 | 69 63 6b 7d 0d 0a 24 54 |Fitzpatr|ick}..$T|
|00002ee0| 61 62 6c 65 7b 7d 0d 0a | 24 43 6f 6d 6d 65 6e 74 |able{}..|$Comment|
|00002ef0| 61 74 6f 72 7b 4a 2e 43 | 2e 20 41 6c 70 65 72 2c |ator{J.C|. Alper,|
|00002f00| 20 4d 2e 44 2e 7d 0d 0a | 0d 0a 43 6f 70 79 72 69 | M.D.}..|..Copyri|
|00002f10| 67 68 74 20 28 63 29 20 | 59 65 61 72 20 42 6f 6f |ght (c) |Year Boo|
|00002f20| 6b 20 4d 65 64 69 63 61 | 6c 20 50 75 62 6c 69 73 |k Medica|l Publis|
|00002f30| 68 65 72 73 2c 20 49 6e | 63 2e 2c 20 31 39 38 39 |hers, In|c., 1989|
|00002f40| 0d 0a 0d 0a 31 39 38 39 | 20 59 65 61 72 20 42 6f |....1989| Year Bo|
|00002f50| 6f 6b 20 6f 66 20 44 65 | 72 6d 61 74 6f 6c 6f 67 |ok of De|rmatolog|
|00002f60| 79 20 28 52 29 0d 0a 0d | 0a 43 68 61 70 74 65 72 |y (R)...|.Chapter|
|00002f70| 20 33 2d 2d 42 75 6c 6c | 6f 75 73 20 44 69 73 65 | 3--Bull|ous Dise|
|00002f80| 61 73 65 73 0d 0a 0d 0a | 2d 2d 2d 2d 2d 2d 2d 2d |ases....|--------|
|00002f90| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002fa0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002fb0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002fc0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002fd0| 2d 2d 2d 2d 2d 2d 2d 2d | 0d 0a 45 76 61 6c 75 61 |--------|..Evalua|
|00002fe0| 74 69 6f 6e 20 6f 66 20 | 74 68 65 20 45 66 66 69 |tion of |the Effi|
|00002ff0| 63 61 63 79 20 6f 66 20 | 54 6f 70 69 63 61 6c 20 |cacy of |Topical |
|00003000| 42 75 66 65 78 61 6d 61 | 63 20 69 6e 20 45 70 69 |Bufexama|c in Epi|
|00003010| 64 65 72 6d 6f 6c 79 73 | 69 73 20 42 75 6c 6c 6f |dermolys|is Bullo|
|00003020| 73 61 0d 0a 53 69 6d 70 | 6c 65 78 3a 20 20 41 20 |sa..Simp|lex: A |
|00003030| 44 6f 75 62 6c 65 2d 42 | 6c 69 6e 64 20 50 6c 61 |Double-B|lind Pla|
|00003040| 63 65 62 6f 2d 43 6f 6e | 74 72 6f 6c 6c 65 64 20 |cebo-Con|trolled |
|00003050| 43 72 6f 73 73 6f 76 65 | 72 20 54 72 69 61 6c 0d |Crossove|r Trial.|
|00003060| 0a 0d 0a 46 69 6e 65 20 | 4a 2d 44 3b 20 4a 6f 68 |...Fine |J-D; Joh|
|00003070| 6e 73 6f 6e 20 4c 0d 0a | 28 55 6e 69 76 20 6f 66 |nson L..|(Univ of|
|00003080| 20 41 6c 61 62 61 6d 61 | 20 69 6e 20 42 69 72 6d | Alabama| in Birm|
|00003090| 69 6e 67 68 61 6d 3b 20 | 42 69 72 6d 69 6e 67 68 |ingham; |Birmingh|
|000030a0| 61 6d 20 56 41 20 4d 65 | 64 20 43 74 72 29 0d 0a |am VA Me|d Ctr)..|
|000030b0| 41 72 63 68 20 44 65 72 | 6d 61 74 6f 6c 20 31 32 |Arch Der|matol 12|
|000030c0| 34 3a 31 36 36 39 2d 31 | 36 37 32 2c 20 4e 6f 76 |4:1669-1|672, Nov|
|000030d0| 65 6d 62 65 72 20 31 39 | 38 38 0d 0a 2d 2d 2d 2d |ember 19|88..----|
|000030e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000030f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003100| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003110| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003120| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 0d 0a 0d 0a |--------|----....|
|00003130| 41 62 73 74 72 61 63 74 | 0d 0a 0d 0a 20 20 20 20 |Abstract|.... |
|00003140| 20 50 61 74 69 65 6e 74 | 73 20 77 69 74 68 20 65 | Patient|s with e|
|00003150| 70 69 64 65 72 6d 6f 6c | 79 73 69 73 20 62 75 6c |pidermol|ysis bul|
|00003160| 6c 6f 73 61 20 73 69 6d | 70 6c 65 78 20 68 61 76 |losa sim|plex hav|
|00003170| 65 20 62 6c 69 73 74 65 | 72 73 2c 20 65 72 6f 73 |e bliste|rs, eros|
|00003180| 69 6f 6e 73 2c 20 61 6e | 64 0d 0a 70 61 69 6e 20 |ions, an|d..pain |
|00003190| 61 66 74 65 72 20 69 6e | 73 69 67 6e 69 66 69 63 |after in|signific|
|000031a0| 61 6e 74 20 69 6e 6a 75 | 72 69 65 73 20 74 6f 20 |ant inju|ries to |
|000031b0| 74 68 65 20 73 6b 69 6e | 2e 20 20 54 68 65 20 64 |the skin|. The d|
|000031c0| 69 73 65 61 73 65 20 63 | 61 6e 20 62 65 0d 0a 69 |isease c|an be..i|
|000031d0| 6e 63 61 70 61 63 69 74 | 61 74 69 6e 67 2c 20 61 |ncapacit|ating, a|
|000031e0| 6e 64 20 6e 6f 20 65 66 | 66 65 63 74 69 76 65 20 |nd no ef|fective |
|000031f0| 74 68 65 72 61 70 79 20 | 68 61 73 20 62 65 65 6e |therapy |has been|
|00003200| 20 66 6f 75 6e 64 2e 20 | 20 42 75 66 65 78 61 6d | found. | Bufexam|
|00003210| 61 63 2c 20 61 0d 0a 6e | 6f 6e 73 74 65 72 6f 69 |ac, a..n|onsteroi|
|00003220| 64 61 6c 20 61 6e 74 69 | 2d 69 6e 66 6c 61 6d 6d |dal anti|-inflamm|
|00003230| 61 74 6f 72 79 20 61 67 | 65 6e 74 2c 20 68 61 73 |atory ag|ent, has|
|00003240| 20 62 65 65 6e 20 72 65 | 70 6f 72 74 65 64 20 74 | been re|ported t|
|00003250| 6f 20 6f 66 66 65 72 20 | 72 65 6c 69 65 66 20 74 |o offer |relief t|
|00003260| 6f 0d 0a 70 61 74 69 65 | 6e 74 73 20 77 69 74 68 |o..patie|nts with|
|00003270| 20 65 70 69 64 65 72 6d | 6f 6c 79 73 69 73 20 62 | epiderm|olysis b|
|00003280| 75 6c 6c 6f 73 61 20 73 | 69 6d 70 6c 65 78 2e 20 |ullosa s|implex. |
|00003290| 20 49 6e 76 65 73 74 69 | 67 61 74 6f 72 73 20 61 | Investi|gators a|
|000032a0| 73 73 65 73 73 65 64 20 | 74 68 65 20 76 61 6c 75 |ssessed |the valu|
|000032b0| 65 0d 0a 6f 66 20 74 6f | 70 69 63 61 6c 20 62 75 |e..of to|pical bu|
|000032c0| 66 65 78 61 6d 61 63 20 | 69 6e 20 61 20 64 6f 75 |fexamac |in a dou|
|000032d0| 62 6c 65 2d 62 6c 69 6e | 64 2c 20 70 6c 61 63 65 |ble-blin|d, place|
|000032e0| 62 6f 2d 63 6f 6e 74 72 | 6f 6c 6c 65 64 20 73 74 |bo-contr|olled st|
|000032f0| 75 64 79 2e 0d 0a 20 20 | 20 20 20 45 69 67 68 74 |udy... | Eight|
|00003300| 20 70 61 74 69 65 6e 74 | 73 20 63 6f 6d 70 6c 65 | patient|s comple|
|00003310| 74 65 64 20 74 68 65 20 | 74 72 69 61 6c 2e 20 20 |ted the |trial. |
|00003320| 45 61 63 68 20 61 70 70 | 6c 69 65 64 20 62 75 66 |Each app|lied buf|
|00003330| 65 78 61 6d 61 63 20 66 | 6f 72 20 34 20 77 65 65 |examac f|or 4 wee|
|00003340| 6b 73 20 61 6e 64 0d 0a | 61 20 70 6c 61 63 65 62 |ks and..|a placeb|
|00003350| 6f 20 66 6f 72 20 61 6e | 6f 74 68 65 72 20 34 2d |o for an|other 4-|
|00003360| 77 65 65 6b 20 70 65 72 | 69 6f 64 2e 20 20 4c 65 |week per|iod. Le|
|00003370| 73 69 6f 6e 61 6c 20 63 | 6f 75 6e 74 73 20 77 65 |sional c|ounts we|
|00003380| 72 65 20 74 61 6b 65 6e | 20 77 65 65 6b 6c 79 2c |re taken| weekly,|
|00003390| 20 61 6e 64 0d 0a 70 61 | 74 69 65 6e 74 73 20 72 | and..pa|tients r|
|000033a0| 65 70 6f 72 74 65 64 20 | 74 68 65 69 72 20 6f 77 |eported |their ow|
|000033b0| 6e 20 72 65 73 70 6f 6e | 73 65 73 20 74 6f 20 74 |n respon|ses to t|
|000033c0| 68 65 20 32 20 63 72 65 | 61 6d 73 2e 0d 0a 20 20 |he 2 cre|ams... |
|000033d0| 20 20 20 53 65 76 65 6e | 20 70 61 74 69 65 6e 74 | Seven| patient|
|000033e0| 73 20 68 61 64 20 6d 6f | 72 65 20 6c 65 73 69 6f |s had mo|re lesio|
|000033f0| 6e 73 20 64 75 72 69 6e | 67 20 74 68 65 20 73 74 |ns durin|g the st|
|00003400| 75 64 79 20 70 65 72 69 | 6f 64 2c 20 77 68 65 74 |udy peri|od, whet|
|00003410| 68 65 72 20 62 75 66 65 | 78 61 6d 61 63 0d 0a 6f |her bufe|xamac..o|
|00003420| 72 20 70 6c 61 63 65 62 | 6f 20 68 61 64 20 62 65 |r placeb|o had be|
|00003430| 65 6e 20 75 73 65 64 2e | 20 20 54 68 6f 75 67 68 |en used.| Though|
|00003440| 20 69 6e 64 69 76 69 64 | 75 61 6c 20 72 65 73 70 | individ|ual resp|
|00003450| 6f 6e 73 65 73 20 76 61 | 72 69 65 64 20 63 6f 6e |onses va|ried con|
|00003460| 73 69 64 65 72 61 62 6c | 79 2c 0d 0a 6e 65 69 74 |siderabl|y,..neit|
|00003470| 68 65 72 20 70 61 69 6e | 20 72 65 6c 69 65 66 20 |her pain| relief |
|00003480| 6e 6f 72 20 69 6d 70 72 | 6f 76 65 6d 65 6e 74 20 |nor impr|ovement |
|00003490| 69 6e 20 68 65 61 6c 69 | 6e 67 20 74 69 6d 65 20 |in heali|ng time |
|000034a0| 77 61 73 20 61 73 73 6f | 63 69 61 74 65 64 20 77 |was asso|ciated w|
|000034b0| 69 74 68 20 61 0d 0a 73 | 70 65 63 69 66 69 63 20 |ith a..s|pecific |
|000034c0| 70 72 65 70 61 72 61 74 | 69 6f 6e 2e 20 20 4f 6e |preparat|ion. On|
|000034d0| 6c 79 20 68 61 6c 66 20 | 6f 66 20 74 68 65 20 70 |ly half |of the p|
|000034e0| 61 74 69 65 6e 74 73 20 | 63 6f 75 6c 64 20 69 64 |atients |could id|
|000034f0| 65 6e 74 69 66 79 20 74 | 68 65 20 74 72 65 61 74 |entify t|he treat|
|00003500| 6d 65 6e 74 0d 0a 70 65 | 72 69 6f 64 20 64 75 72 |ment..pe|riod dur|
|00003510| 69 6e 67 20 77 68 69 63 | 68 20 62 75 66 65 78 61 |ing whic|h bufexa|
|00003520| 6d 61 63 20 77 61 73 20 | 61 64 6d 69 6e 69 73 74 |mac was |administ|
|00003530| 65 72 65 64 2e 0d 0a 20 | 20 20 20 20 49 6e 20 74 |ered... | In t|
|00003540| 68 69 73 20 73 6d 61 6c | 6c 20 73 61 6d 70 6c 65 |his smal|l sample|
|00003550| 2c 20 62 75 66 65 78 61 | 6d 61 63 20 77 61 73 20 |, bufexa|mac was |
|00003560| 6e 6f 74 20 66 6f 75 6e | 64 20 74 6f 20 62 65 20 |not foun|d to be |
|00003570| 61 6e 20 65 66 66 65 63 | 74 69 76 65 20 74 72 65 |an effec|tive tre|
|00003580| 61 74 6d 65 6e 74 0d 0a | 66 6f 72 20 65 70 69 64 |atment..|for epid|
|00003590| 65 72 6d 6f 6c 79 73 69 | 73 20 62 75 6c 6c 6f 73 |ermolysi|s bullos|
|000035a0| 61 20 73 69 6d 70 6c 65 | 78 2e 20 20 53 74 75 64 |a simple|x. Stud|
|000035b0| 69 65 73 20 75 73 69 6e | 67 20 61 6e 69 6d 61 6c |ies usin|g animal|
|000035c0| 73 20 61 6e 64 20 68 75 | 6d 61 6e 20 62 65 69 6e |s and hu|man bein|
|000035d0| 67 73 20 68 61 76 65 0d | 0a 73 68 6f 77 6e 20 74 |gs have.|.shown t|
|000035e0| 68 65 20 61 67 65 6e 74 | 20 74 6f 20 62 65 20 6f |he agent| to be o|
|000035f0| 66 20 76 61 6c 75 65 20 | 66 6f 72 20 74 72 65 61 |f value |for trea|
|00003600| 74 69 6e 67 20 69 6e 66 | 6c 61 6d 6d 61 74 6f 72 |ting inf|lammator|
|00003610| 79 20 73 6b 69 6e 20 64 | 69 73 65 61 73 65 2c 20 |y skin d|isease, |
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|00004380| 2e 0d 0a 54 68 69 73 20 | 73 75 62 73 65 74 20 6f |...This |subset o|
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|000043a0| 68 61 72 61 63 74 65 72 | 69 7a 65 64 20 62 79 20 |haracter|ized by |
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|000043c0| 73 69 6f 6e 2c 20 63 68 | 72 6f 6e 69 63 69 74 79 |sion, ch|ronicity|
|000043d0| 2c 0d 0a 6c 61 63 6b 20 | 6f 66 20 73 65 72 69 6f |,..lack |of serio|
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|00004420| 6e 74 72 61 6c 65 73 69 | 6f 6e 61 6c 20 63 6f 72 |ntralesi|onal cor|
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|00004440| 67 20 34 2d 32 29 2e 0d | 0a 0d 0a 50 6f 73 74 2d |g 4-2)..|...Post-|
|00004450| 43 6f 6d 6d 65 6e 74 0d | 0a 0d 0a 20 20 20 20 20 |Comment.|... |
|00004460| 54 68 65 20 70 72 65 73 | 65 6e 63 65 20 6f 66 20 |The pres|ence of |
|00004470| 68 79 70 65 72 74 72 6f | 70 68 69 63 20 66 6f 72 |hypertro|phic for|
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|00004490| 6c 65 73 69 6f 6e 73 20 | 69 6e 20 6c 75 70 75 73 |lesions |in lupus|
|000044a0| 0d 0a 65 72 79 74 68 65 | 6d 61 74 6f 73 75 73 20 |..erythe|matosus |
|000044b0| 64 6f 65 73 20 6e 6f 74 | 20 69 64 65 6e 74 69 66 |does not| identif|
|000044c0| 79 20 61 20 73 70 65 63 | 69 66 69 63 20 73 75 62 |y a spec|ific sub|
|000044d0| 73 65 74 20 6f 66 20 70 | 61 74 69 65 6e 74 73 2e |set of p|atients.|
|000044e0| 20 20 41 6c 74 68 6f 75 | 67 68 20 74 68 65 73 65 | Althou|gh these|
|000044f0| 0d 0a 6c 65 73 69 6f 6e | 73 20 6d 61 79 20 62 65 |..lesion|s may be|
|00004500| 20 64 69 66 66 69 63 75 | 6c 74 20 74 6f 20 74 72 | difficu|lt to tr|
|00004510| 65 61 74 2c 20 74 68 69 | 73 20 73 74 75 64 79 20 |eat, thi|s study |
|00004520| 73 75 67 67 65 73 74 73 | 20 74 68 61 74 20 74 68 |suggests| that th|
|00004530| 65 20 69 6e 74 72 61 6c | 65 73 69 6f 6e 61 6c 0d |e intral|esional.|
|00004540| 0a 69 6e 6a 65 63 74 69 | 6f 6e 20 6f 66 20 63 6f |.injecti|on of co|
|00004550| 72 74 69 63 6f 73 74 65 | 72 6f 69 64 73 20 69 73 |rticoste|roids is|
|00004560| 20 6f 66 20 76 61 6c 75 | 65 2e 2d 2d 4e 2e 41 2e | of valu|e.--N.A.|
|00004570| 20 53 6f 74 65 72 2c 20 | 4d 2e 44 2e 0d 0a 24 55 | Soter, |M.D...$U|
|00004580| 6e 69 71 75 65 5f 49 44 | 7b 59 52 42 30 34 38 30 |nique_ID|{YRB0480|
|00004590| 35 7d 0d 0a 24 54 69 74 | 6c 65 7b 50 72 65 67 6e |5}..$Tit|le{Pregn|
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|000045b0| 20 50 72 6f 67 6e 6f 73 | 74 69 63 20 49 6e 64 69 | Prognos|tic Indi|
|000045c0| 63 61 74 6f 72 73 20 61 | 6e 64 20 52 65 73 70 6f |cators a|nd Respo|
|000045d0| 6e 73 65 20 74 6f 20 54 | 72 65 61 74 6d 65 6e 74 |nse to T|reatment|
|000045e0| 7d 0d 0a 24 41 75 74 68 | 6f 72 7b 0d 0a 45 6e 67 |}..$Auth|or{..Eng|
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|00004630| 74 2c 20 4d 0d 0a 57 61 | 6c 70 6f 72 74 2c 20 4d |t, M..Wa|lport, M|
|00004640| 4a 0d 0a 48 75 67 68 65 | 73 2c 20 47 52 56 7d 0d |J..Hughe|s, GRV}.|
|00004650| 0a 24 41 66 66 69 6c 69 | 61 74 69 6f 6e 7b 52 6f |.$Affili|ation{Ro|
|00004660| 79 61 6c 20 50 6f 73 74 | 67 72 61 64 20 4d 65 64 |yal Post|grad Med|
|00004670| 20 53 63 68 6f 6f 6c 2c | 20 51 75 65 65 6e 20 43 | School,| Queen C|
|00004680| 68 61 72 6c 6f 74 74 65 | 27 73 20 4d 61 74 65 72 |harlotte|'s Mater|
|00004690| 6e 69 74 79 20 48 6f 73 | 70 2c 20 4c 6f 6e 64 6f |nity Hos|p, Londo|
|000046a0| 6e 7d 0d 0a 24 53 75 62 | 6a 65 63 74 7b 50 72 65 |n}..$Sub|ject{Pre|
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|000046c0| 69 6e 67 3b 0d 0a 4c 75 | 70 75 73 20 64 75 72 69 |ing;..Lu|pus duri|
|000046d0| 6e 67 20 70 72 65 67 6e | 61 6e 63 79 7d 0d 0a 24 |ng pregn|ancy}..$|
|000046e0| 4a 6f 75 72 6e 61 6c 7b | 51 20 4a 20 4d 65 64 7d |Journal{|Q J Med}|
|000046f0| 0d 0a 24 56 6f 6c 75 6d | 65 7b 36 36 7d 0d 0a 24 |..$Volum|e{66}..$|
|00004700| 50 61 67 65 7b 31 32 35 | 2d 31 33 36 7d 0d 0a 24 |Page{125|-136}..$|
|00004710| 44 61 74 65 7b 46 65 62 | 72 75 61 72 79 20 31 39 |Date{Feb|ruary 19|
|00004720| 38 38 7d 0d 0a 24 59 42 | 56 6f 6c 7b 31 39 38 39 |88}..$YB|Vol{1989|
|00004730| 20 59 65 61 72 20 42 6f | 6f 6b 20 6f 66 20 44 65 | Year Bo|ok of De|
|00004740| 72 6d 61 74 6f 6c 6f 67 | 79 7d 0d 0a 24 43 68 61 |rmatolog|y}..$Cha|
|00004750| 70 74 65 72 7b 34 2d 32 | 7d 0d 0a 24 59 42 45 64 |pter{4-2|}..$YBEd|
|00004760| 69 74 6f 72 7b 44 72 73 | 2e 20 53 6f 62 65 72 20 |itor{Drs|. Sober |
|00004770| 61 6e 64 20 46 69 74 7a | 70 61 74 72 69 63 6b 7d |and Fitz|patrick}|
|00004780| 0d 0a 24 54 61 62 6c 65 | 7b 7d 0d 0a 24 43 6f 6d |..$Table|{}..$Com|
|00004790| 6d 65 6e 74 61 74 6f 72 | 7b 53 2e 4c 2e 20 4d 6f |mentator|{S.L. Mo|
|000047a0| 73 63 68 65 6c 6c 61 2c | 20 4d 2e 44 2e 7d 0d 0a |schella,| M.D.}..|
|000047b0| 0d 0a 43 6f 70 79 72 69 | 67 68 74 20 28 63 29 20 |..Copyri|ght (c) |
|000047c0| 59 65 61 72 20 42 6f 6f | 6b 20 4d 65 64 69 63 61 |Year Boo|k Medica|
|000047d0| 6c 20 50 75 62 6c 69 73 | 68 65 72 73 2c 20 49 6e |l Publis|hers, In|
|000047e0| 63 2e 2c 20 31 39 38 39 | 0d 0a 0d 0a 31 39 38 39 |c., 1989|....1989|
|000047f0| 20 59 65 61 72 20 42 6f | 6f 6b 20 6f 66 20 44 65 | Year Bo|ok of De|
|00004800| 72 6d 61 74 6f 6c 6f 67 | 79 20 28 52 29 0d 0a 0d |rmatolog|y (R)...|
|00004810| 0a 43 68 61 70 74 65 72 | 20 34 2d 2d 43 6f 6c 6c |.Chapter| 4--Coll|
|00004820| 61 67 65 6e 20 56 61 73 | 63 75 6c 61 72 20 44 69 |agen Vas|cular Di|
|00004830| 73 65 61 73 65 0d 0a 0d | 0a 2d 2d 2d 2d 2d 2d 2d |sease...|.-------|
|00004840| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004850| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004860| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004870| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004880| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 0d 0a 50 72 65 67 6e |--------|-..Pregn|
|00004890| 61 6e 63 79 20 61 6e 64 | 20 4c 75 70 75 73 3a 20 |ancy and| Lupus: |
|000048a0| 20 50 72 6f 67 6e 6f 73 | 74 69 63 20 49 6e 64 69 | Prognos|tic Indi|
|000048b0| 63 61 74 6f 72 73 20 61 | 6e 64 20 52 65 73 70 6f |cators a|nd Respo|
|000048c0| 6e 73 65 20 74 6f 20 54 | 72 65 61 74 6d 65 6e 74 |nse to T|reatment|
|000048d0| 0d 0a 0d 0a 45 6e 67 6c | 65 72 74 20 48 4a 3b 20 |....Engl|ert HJ; |
|000048e0| 44 65 72 75 65 20 47 4d | 3b 20 4c 6f 69 7a 6f 75 |Derue GM|; Loizou|
|000048f0| 20 53 3b 20 48 61 77 6b | 69 6e 73 20 44 46 3b 20 | S; Hawk|ins DF; |
|00004900| 45 6c 64 65 72 20 4d 47 | 3b 20 44 65 20 53 77 69 |Elder MG|; De Swi|
|00004910| 65 74 20 4d 3b 20 57 61 | 6c 70 6f 72 74 20 4d 4a |et M; Wa|lport MJ|
|00004920| 3b 0d 0a 48 75 67 68 65 | 73 20 47 52 56 0d 0a 28 |;..Hughe|s GRV..(|
|00004930| 52 6f 79 61 6c 20 50 6f | 73 74 67 72 61 64 20 4d |Royal Po|stgrad M|
|00004940| 65 64 20 53 63 68 6f 6f | 6c 2c 20 51 75 65 65 6e |ed Schoo|l, Queen|
|00004950| 20 43 68 61 72 6c 6f 74 | 74 65 27 73 20 4d 61 74 | Charlot|te's Mat|
|00004960| 65 72 6e 69 74 79 20 48 | 6f 73 70 2c 20 4c 6f 6e |ernity H|osp, Lon|
|00004970| 64 6f 6e 29 0d 0a 51 20 | 4a 20 4d 65 64 20 36 36 |don)..Q |J Med 66|
|00004980| 3a 31 32 35 2d 31 33 36 | 2c 20 46 65 62 72 75 61 |:125-136|, Februa|
|00004990| 72 79 20 31 39 38 38 0d | 0a 2d 2d 2d 2d 2d 2d 2d |ry 1988.|.-------|
|000049a0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000049b0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000049c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000049d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000049e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 0d 0a 0d 0a 41 62 73 |--------|-....Abs|
|000049f0| 74 72 61 63 74 0d 0a 0d | 0a 20 20 20 20 20 54 68 |tract...|. Th|
|00004a00| 65 20 61 76 61 69 6c 61 | 62 6c 65 20 64 61 74 61 |e availa|ble data|
|00004a10| 20 6f 6e 20 70 72 65 67 | 6e 61 6e 63 79 20 6f 75 | on preg|nancy ou|
|00004a20| 74 63 6f 6d 65 20 69 6e | 20 77 6f 6d 65 6e 20 77 |tcome in| women w|
|00004a30| 69 74 68 20 73 79 73 74 | 65 6d 69 63 20 6c 75 70 |ith syst|emic lup|
|00004a40| 75 73 0d 0a 65 72 79 74 | 68 65 6d 61 74 6f 73 75 |us..eryt|hematosu|
|00004a50| 73 20 28 53 4c 45 29 20 | 61 72 65 20 69 6e 63 6f |s (SLE) |are inco|
|00004a60| 6e 63 6c 75 73 69 76 65 | 2e 20 20 57 68 65 72 65 |nclusive|. Where|
|00004a70| 61 73 20 73 6f 6d 65 20 | 61 75 74 68 6f 72 73 20 |as some |authors |
|00004a80| 66 6f 75 6e 64 20 74 68 | 61 74 20 53 4c 45 20 64 |found th|at SLE d|
|00004a90| 69 64 0d 0a 6e 6f 74 20 | 61 66 66 65 63 74 20 70 |id..not |affect p|
|00004aa0| 72 65 67 6e 61 6e 63 79 | 20 6f 75 74 63 6f 6d 65 |regnancy| outcome|
|00004ab0| 2c 20 6f 74 68 65 72 73 | 20 72 65 70 6f 72 74 65 |, others| reporte|
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|00004bb0| 70 61 74 69 65 6e 74 73 | 20 77 69 74 68 20 53 4c |patients| with SL|
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|00004be0| 6e 74 20 72 65 6e 61 6c | 20 69 6d 70 61 69 72 6d |nt renal| impairm|
|00004bf0| 65 6e 74 2e 0d 0a 20 20 | 20 20 20 42 61 73 65 64 |ent... | Based|
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